The role of spatial proximity in genome regulation

Abstract: Imaging and genomic technologies have opened up large-scale interrogation of 3D genome organisation in the cell nucleus. This has revealed multiple layers of organisation and at different scales, including distal interactions of genome compartments, topologically associating domains (TADs) and specific cis interactions between either active or repressive elements. Progress is being made toward understanding the molecular mechanisms that mediate these layers of organisation. However, understanding the functional significance of 3D organisation across genomic scales lags behind. To what extent does 3D organisation drive genome regulation, or are some aspects of 3D organisation simply an emergent property of genome and protein functions? In this talk I will describe our efforts to determine the functional significance of the 3D genome – from the action of polycomb complexes in bridging distal interactions between repressed loci, to the role of TADs and enhancer-promoter proximity in enhancer-driven gene activation.

biochemistrycancer biologychemical biologycell biologydevelopmental biologydrug discoveryevolutiongeneticsimmunologymolecular biologymicrobiologyneuroscienceplant sciencessystems biologybiotechnologybiological techniquesbiophysics

Audience: researchers in the discipline

( video )

Comments: Organizers can be contacted at m.tariq@lums.edu.pk or 22100032@lums.edu.pk for the zoom link.

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Colloquium zooming Molecular & Cellular Biology LUMS

Series comments: Zooming Molecular & Cellular Biology Colloquium was initiated on July 28th, 2020 by the Biology department at Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS). The series follows through various topics which come under the ambit of Molecular and Cellular Biology and we’ve had the pleasure and honor of hosting some of the most knowledgeable scientists from around the globe. Organizers can be reached out at 24100162@lums.edu.pk or 24100001@lums.edu.pk for the Zoom link of individual talks. All lectures are LIVE streamed on SBASSE's official Facebook page.

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